Tickets are still available for the 7pm match inside Stadium 1.
Serena is returning this week to the tour for the first time after giving birth to daughter Alexis Olympia in September.
The last time the Williams sisters met was in last year’s Australian Open final, when Serena was six weeks pregnant. She won that title for her 23rd Grand Slam, an Open Era record.
Serena leads their head-to-head 17-11 overall, Venus having most recently beaten her little sister at the Rogers Cup in Montreal.
If you’re interested in tickets, you can find them via the button below.
The match will be aired on Tennis Channel as scheduled, as well as ESPNEWS, the WatchESPN app as well as WTA TV, the official streaming service of the women’s tour (match available only in certain regions).