In 2025, Anastasia Zakharova reached her first WTA Tour semifinal in Cleveland (l. eventual champion Cirstea), made the second round at both Wimbledon and the US Open, and recorded her first two Top 50 wins (d. Vekic at Queen’s Club; d. Baptiste in Cleveland). She made her Top 100 debut on June 16 and climbed to a career-high No. 79 on September 15.